{"product_id":"mrp8-vesicle-kit","title":"Human MRP8 Vesicle Kit (HEK293 derived) | ABCC11 | Steroid \u0026 Nucleotide Transport | 100 Reactions","description":"\u003ch2\u003eHuman MRP8 Vesicle Kit – Inside-Out Membrane Vesicles for Steroid Sulfate, Bile Acid and Nucleoside Analogue Transport Studies\u003c\/h2\u003e\n\n\u003cp\u003eThe Human MRP8 Vesicle Kit (HEK293 derived) provides ready-to-use inside-out membrane vesicles for ATP-dependent transport studies of MRP8 (ABCC11). MRP8 is expressed in brain, mammary gland, liver, and testes, and transports a distinctive substrate profile including steroid sulfates, bile acids, cAMP, and nucleoside monophosphate analogues. It is of particular relevance in breast cancer DDI studies, CNS drug development, and metabolic profiling of steroid conjugates.\u003c\/p\u003e\n\n\u003ch3\u003eTransporter Profile\u003c\/h3\u003e\n\u003cp\u003eMRP8 (ABCC11) transports steroid sulfates (DHEAS, E1S), monoanionic bile acids, cAMP, glutathione conjugates, and nucleoside monophosphate analogues. Its expression in the mammary gland is of interest in breast cancer research, and its CNS expression is relevant for brain drug distribution. Mouse and rat MRP8 isoforms are available on request. Key substrates: DHEAS (dehydroepiandrosterone-3-sulfate), E1S (estrone-3-sulfate), LTC₄, cAMP.\u003c\/p\u003e\n\n\u003ch3\u003eTechnical Specifications\u003c\/h3\u003e\n\u003ctable\u003e\n\u003ctr\u003e\n\u003cth\u003eParameter\u003c\/th\u003e\n\u003cth\u003eSpecification\u003c\/th\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eTransporter\u003c\/td\u003e\n\u003ctd\u003eHuman MRP8 (Multidrug Resistance-Associated Protein 8) (ABCC11)\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eExpression system\u003c\/td\u003e\n\u003ctd\u003eHEK293 (transient overexpression)\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eVesicle type\u003c\/td\u003e\n\u003ctd\u003eInside-out membrane vesicles\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eReactions per kit\u003c\/td\u003e\n\u003ctd\u003e100\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eATP\/AMP transport ratio\u003c\/td\u003e\n\u003ctd\u003e\u0026gt;5\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eDetection compatibility\u003c\/td\u003e\n\u003ctd\u003eRadiolabel, LC-MS\/MS\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eStorage\u003c\/td\u003e\n\u003ctd\u003e−80 °C (supplied on dry ice)\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eKit contents\u003c\/td\u003e\n\u003ctd\u003eVesicles, ATP, AMP, reaction buffer, wash buffer, CoA\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eManufacturer\u003c\/td\u003e\n\u003ctd\u003eCell4Pharma (Netherlands)\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eDistributor DACH\u003c\/td\u003e\n\u003ctd\u003eSeamlessBio GmbH, Passau\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/table\u003e\n\n\u003ch3\u003eApplications\u003c\/h3\u003e\n\u003ctable\u003e\n\u003ctr\u003e\n\u003cth\u003eApplication\u003c\/th\u003e\n\u003cth\u003eDescription\u003c\/th\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cstrong\u003eSteroid sulfate efflux studies\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003eCharacterise transport of DHEAS, estrone sulfate, and other steroid sulfate conjugates — relevant for understanding hormonal drug distribution and metabolite efflux in breast and hepatic tissues.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cstrong\u003eBreast cancer \/ mammary tissue DDI\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003eMRP8 in mammary tissue mediates efflux of steroid hormones and certain anticancer drugs. Relevant for breast cancer drug development and understanding hormonal drug interactions.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cstrong\u003eCNS and bile acid transport\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003eCNS expression of MRP8 may restrict brain exposure of steroid sulfate conjugates. Bile acid transport capacity makes MRP8 relevant in hepatic cholestatic studies alongside BSEP and MRP2.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/table\u003e\n\n\u003ch3\u003eAssay Principle\u003c\/h3\u003e\n\u003cp\u003eInside-out membrane vesicles present the cytoplasmic face of the transporter to the assay buffer, allowing ATP-dependent substrate uptake into the vesicle lumen. Incubate vesicles with test compound and probe substrate in the presence of ATP (transport) or AMP (background control). Stop reaction with cold wash buffer, separate vesicles by filtration, and quantify accumulated substrate by LC-MS\/MS, radiolabel, or fluorescence. The ATP\/AMP ratio provides the assay window for reliable IC₅₀ determination.\u003c\/p\u003e\n\n\u003ch3\u003eComplete Cell4Pharma Kit Portfolio at SeamlessBio\u003c\/h3\u003e\n\u003cp\u003eOrder all ABC transporter vesicle kits from a single EU source — fast cold-chain delivery, guaranteed ATP\/AMP ratios, full documentation.\u003c\/p\u003e\n\u003ctable\u003e\n\u003ctr\u003e\n\u003cth\u003eKit\u003c\/th\u003e\n\u003cth\u003eTransporter\u003c\/th\u003e\n\u003cth\u003eGene\u003c\/th\u003e\n\u003cth\u003eATP\/AMP Ratio\u003c\/th\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eHuman BCRP Vesicle Kit\u003c\/td\u003e\n\u003ctd\u003eBCRP\u003c\/td\u003e\n\u003ctd\u003eABCG2\u003c\/td\u003e\n\u003ctd\u003e\u0026gt;10\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eHuman BSEP Vesicle Kit\u003c\/td\u003e\n\u003ctd\u003eBSEP\u003c\/td\u003e\n\u003ctd\u003eABCB11\u003c\/td\u003e\n\u003ctd\u003e\u0026gt;10\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eHuman MRP1 Vesicle Kit\u003c\/td\u003e\n\u003ctd\u003eMRP1\u003c\/td\u003e\n\u003ctd\u003eABCC1\u003c\/td\u003e\n\u003ctd\u003e\u0026gt;5\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eHuman MRP2 Vesicle Kit\u003c\/td\u003e\n\u003ctd\u003eMRP2\u003c\/td\u003e\n\u003ctd\u003eABCC2\u003c\/td\u003e\n\u003ctd\u003e\u0026gt;20\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eHuman MRP3 Vesicle Kit\u003c\/td\u003e\n\u003ctd\u003eMRP3\u003c\/td\u003e\n\u003ctd\u003eABCC3\u003c\/td\u003e\n\u003ctd\u003e\u0026gt;5\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eHuman MRP4 Vesicle Kit\u003c\/td\u003e\n\u003ctd\u003eMRP4\u003c\/td\u003e\n\u003ctd\u003eABCC4\u003c\/td\u003e\n\u003ctd\u003e\u0026gt;5\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eHuman MRP5 Vesicle Kit\u003c\/td\u003e\n\u003ctd\u003eMRP5\u003c\/td\u003e\n\u003ctd\u003eABCC5\u003c\/td\u003e\n\u003ctd\u003e\u0026gt;5\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eHuman MRP8 Vesicle Kit\u003c\/td\u003e\n\u003ctd\u003eMRP8\u003c\/td\u003e\n\u003ctd\u003eABCC11\u003c\/td\u003e\n\u003ctd\u003e\u0026gt;5\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eHuman Pgp Vesicle Kit\u003c\/td\u003e\n\u003ctd\u003eP-gp \/ MDR1\u003c\/td\u003e\n\u003ctd\u003eABCB1\u003c\/td\u003e\n\u003ctd\u003e\u0026gt;5\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eHuman Pgp + FluoPgp Kit\u003c\/td\u003e\n\u003ctd\u003eP-gp \/ MDR1\u003c\/td\u003e\n\u003ctd\u003eABCB1\u003c\/td\u003e\n\u003ctd\u003e\u0026gt;5\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eHuman Control Vesicle Kit\u003c\/td\u003e\n\u003ctd\u003e—\u003c\/td\u003e\n\u003ctd\u003eHEK293 empty vector\u003c\/td\u003e\n\u003ctd\u003e—\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/table\u003e\n\n\u003ch3\u003eQuality \u0026amp; Regulatory Compliance\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003eProduced by \u003cstrong\u003eCell4Pharma\u003c\/strong\u003e — specialist manufacturer of ABC transporter vesicle systems\u003c\/li\u003e\n\u003cli\u003eGuaranteed ATP\/AMP transport ratio \u003cstrong\u003e\u0026gt;5\u003c\/strong\u003e per lot\u003c\/li\u003e\n\u003cli\u003eLarge, uniform batches — maximum lot-to-lot consistency\u003c\/li\u003e\n\u003cli\u003eLot-specific QC report + data sheet included with every kit\u003c\/li\u003e\n\u003cli\u003eAligned with \u003cstrong\u003eFDA DDI Guidance (2020)\u003c\/strong\u003e and \u003cstrong\u003eEMA DDI Guideline (2013\/2022)\u003c\/strong\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\n\u003ch3\u003eWhy Order via SeamlessBio?\u003c\/h3\u003e\n\u003ctable\u003e\n\u003ctr\u003e\n\u003cth\u003eAdvantage\u003c\/th\u003e\n\u003cth\u003eDescription\u003c\/th\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e✅ EU warehouse stock\u003c\/td\u003e\n\u003ctd\u003eFast cold-chain delivery across Germany, Austria, Switzerland and the EU\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e✅ Direct contact\u003c\/td\u003e\n\u003ctd\u003eSpeak to a scientist, not a call centre — in German or English\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e✅ Full documentation\u003c\/td\u003e\n\u003ctd\u003eData sheet, QC report and invoice with every shipment\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e✅ Batch reservation\u003c\/td\u003e\n\u003ctd\u003eReserve a specific lot for your entire project duration\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e✅ Complete portfolio\u003c\/td\u003e\n\u003ctd\u003eAll 11 Cell4Pharma kits from one source — BCRP, BSEP, MRP1–8, Pgp, Control\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/table\u003e\n\n\u003cp\u003eOrder or request pricing: \u003ca href=\"mailto:info@seamlessbio.de\"\u003einfo@seamlessbio.de\u003c\/a\u003e | +49 851 37932226\u003c\/p\u003e\n\n\u003ch3\u003eFrequently Asked Questions\u003c\/h3\u003e\n\u003ch4\u003eIs MRP8 available for mouse and rat isoforms?\u003c\/h4\u003e\n\u003cp\u003eYes — mouse and rat MRP8 (ABCC11) isoforms are available on request from Cell4Pharma. Please contact us for lead times and pricing: info@seamlessbio.de\u003c\/p\u003e","brand":"Cell4Pharma","offers":[{"title":"100","offer_id":58031523627389,"sku":"C4PVK010","price":1450.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0916\/3338\/5853\/files\/MRP8-2-scaled.jpg?v=1776025630","url":"https:\/\/shop.seamlessbio.de\/en\/products\/mrp8-vesicle-kit","provider":"SeamlessBio","version":"1.0","type":"link"}