{"product_id":"mrp5-vesicle-kit","title":"Human MRP5 Vesicle Kit (HEK293 derived) | ABCC5 | Nucleotide \u0026 Organic Anion Transport | 100 Reactions","description":"\u003ch2\u003eHuman MRP5 Vesicle Kit – Inside-Out Membrane Vesicles for Ubiquitous Organic Anion and Cyclic Nucleotide Transport Studies\u003c\/h2\u003e\n\n\u003cp\u003eThe Human MRP5 Vesicle Kit (HEK293 derived) provides ready-to-use inside-out membrane vesicles for ATP-dependent transport studies of MRP5 (ABCC5). Unlike other MRPs with organ-specific expression, MRP5 is ubiquitously expressed throughout the body and handles cyclic nucleotides, nucleotide analogues, and organic anions. It is particularly relevant for antiviral and anticancer nucleoside analogues and has been identified at the blood-brain barrier.\u003c\/p\u003e\n\n\u003ch3\u003eTransporter Profile\u003c\/h3\u003e\n\u003cp\u003eMRP5 (ABCC5) is ubiquitously expressed in heart, brain, skeletal muscle, testes, and many other tissues. It transports cyclic nucleotides (cAMP, cGMP), organic anions, glutathione conjugates, and nucleoside monophosphate analogues. Its broad tissue distribution means MRP5 inhibition can potentially affect drug distribution in multiple compartments. Key substrates: cAMP, cGMP, PMEA, fluorescein. Less well characterised than MRP1–4; this kit enables systematic in vitro profiling.\u003c\/p\u003e\n\n\u003ch3\u003eTechnical Specifications\u003c\/h3\u003e\n\u003ctable\u003e\n\u003ctr\u003e\n\u003cth\u003eParameter\u003c\/th\u003e\n\u003cth\u003eSpecification\u003c\/th\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eTransporter\u003c\/td\u003e\n\u003ctd\u003eHuman MRP5 (Multidrug Resistance-Associated Protein 5) (ABCC5)\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eExpression system\u003c\/td\u003e\n\u003ctd\u003eHEK293 (transient overexpression)\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eVesicle type\u003c\/td\u003e\n\u003ctd\u003eInside-out membrane vesicles\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eReactions per kit\u003c\/td\u003e\n\u003ctd\u003e100\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eATP\/AMP transport ratio\u003c\/td\u003e\n\u003ctd\u003e\u0026gt;5\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eDetection compatibility\u003c\/td\u003e\n\u003ctd\u003eRadiolabel, LC-MS\/MS\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eStorage\u003c\/td\u003e\n\u003ctd\u003e−80 °C (supplied on dry ice)\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eKit contents\u003c\/td\u003e\n\u003ctd\u003eVesicles, ATP, AMP, reaction buffer, wash buffer, CoA\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eManufacturer\u003c\/td\u003e\n\u003ctd\u003eCell4Pharma (Netherlands)\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eDistributor DACH\u003c\/td\u003e\n\u003ctd\u003eSeamlessBio GmbH, Passau\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/table\u003e\n\n\u003ch3\u003eApplications\u003c\/h3\u003e\n\u003ctable\u003e\n\u003ctr\u003e\n\u003cth\u003eApplication\u003c\/th\u003e\n\u003cth\u003eDescription\u003c\/th\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cstrong\u003eNucleoside analogue transport profiling\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003eScreen anticancer and antiviral nucleoside monophosphate analogues as MRP5 substrates — relevant for understanding intracellular drug accumulation and resistance mechanisms.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cstrong\u003eCNS drug distribution\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003eMRP5 expression at the blood-brain barrier may contribute to restricted CNS penetration of organic anions. Relevant for CNS drug development programs.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cstrong\u003eBroad tissue distribution profiling\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003eCharacterise MRP5-mediated efflux in non-liver, non-intestine tissues — cardiac, testicular, and CNS compartments where ubiquitous expression is pharmacologically relevant.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/table\u003e\n\n\u003ch3\u003eAssay Principle\u003c\/h3\u003e\n\u003cp\u003eInside-out membrane vesicles present the cytoplasmic face of the transporter to the assay buffer, allowing ATP-dependent substrate uptake into the vesicle lumen. Incubate vesicles with test compound and probe substrate in the presence of ATP (transport) or AMP (background control). Stop reaction with cold wash buffer, separate vesicles by filtration, and quantify accumulated substrate by LC-MS\/MS, radiolabel, or fluorescence. The ATP\/AMP ratio provides the assay window for reliable IC₅₀ determination.\u003c\/p\u003e\n\n\u003ch3\u003eComplete Cell4Pharma Kit Portfolio at SeamlessBio\u003c\/h3\u003e\n\u003cp\u003eOrder all ABC transporter vesicle kits from a single EU source — fast cold-chain delivery, guaranteed ATP\/AMP ratios, full documentation.\u003c\/p\u003e\n\u003ctable\u003e\n\u003ctr\u003e\n\u003cth\u003eKit\u003c\/th\u003e\n\u003cth\u003eTransporter\u003c\/th\u003e\n\u003cth\u003eGene\u003c\/th\u003e\n\u003cth\u003eATP\/AMP Ratio\u003c\/th\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eHuman BCRP Vesicle Kit\u003c\/td\u003e\n\u003ctd\u003eBCRP\u003c\/td\u003e\n\u003ctd\u003eABCG2\u003c\/td\u003e\n\u003ctd\u003e\u0026gt;10\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eHuman BSEP Vesicle Kit\u003c\/td\u003e\n\u003ctd\u003eBSEP\u003c\/td\u003e\n\u003ctd\u003eABCB11\u003c\/td\u003e\n\u003ctd\u003e\u0026gt;10\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eHuman MRP1 Vesicle Kit\u003c\/td\u003e\n\u003ctd\u003eMRP1\u003c\/td\u003e\n\u003ctd\u003eABCC1\u003c\/td\u003e\n\u003ctd\u003e\u0026gt;5\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eHuman MRP2 Vesicle Kit\u003c\/td\u003e\n\u003ctd\u003eMRP2\u003c\/td\u003e\n\u003ctd\u003eABCC2\u003c\/td\u003e\n\u003ctd\u003e\u0026gt;20\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eHuman MRP3 Vesicle Kit\u003c\/td\u003e\n\u003ctd\u003eMRP3\u003c\/td\u003e\n\u003ctd\u003eABCC3\u003c\/td\u003e\n\u003ctd\u003e\u0026gt;5\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eHuman MRP4 Vesicle Kit\u003c\/td\u003e\n\u003ctd\u003eMRP4\u003c\/td\u003e\n\u003ctd\u003eABCC4\u003c\/td\u003e\n\u003ctd\u003e\u0026gt;5\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eHuman MRP5 Vesicle Kit\u003c\/td\u003e\n\u003ctd\u003eMRP5\u003c\/td\u003e\n\u003ctd\u003eABCC5\u003c\/td\u003e\n\u003ctd\u003e\u0026gt;5\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eHuman MRP8 Vesicle Kit\u003c\/td\u003e\n\u003ctd\u003eMRP8\u003c\/td\u003e\n\u003ctd\u003eABCC11\u003c\/td\u003e\n\u003ctd\u003e\u0026gt;5\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eHuman Pgp Vesicle Kit\u003c\/td\u003e\n\u003ctd\u003eP-gp \/ MDR1\u003c\/td\u003e\n\u003ctd\u003eABCB1\u003c\/td\u003e\n\u003ctd\u003e\u0026gt;5\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eHuman Pgp + FluoPgp Kit\u003c\/td\u003e\n\u003ctd\u003eP-gp \/ MDR1\u003c\/td\u003e\n\u003ctd\u003eABCB1\u003c\/td\u003e\n\u003ctd\u003e\u0026gt;5\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eHuman Control Vesicle Kit\u003c\/td\u003e\n\u003ctd\u003e—\u003c\/td\u003e\n\u003ctd\u003eHEK293 empty vector\u003c\/td\u003e\n\u003ctd\u003e—\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/table\u003e\n\n\u003ch3\u003eQuality \u0026amp; Regulatory Compliance\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003eProduced by \u003cstrong\u003eCell4Pharma\u003c\/strong\u003e — specialist manufacturer of ABC transporter vesicle systems\u003c\/li\u003e\n\u003cli\u003eGuaranteed ATP\/AMP transport ratio \u003cstrong\u003e\u0026gt;5\u003c\/strong\u003e per lot\u003c\/li\u003e\n\u003cli\u003eLarge, uniform batches — maximum lot-to-lot consistency\u003c\/li\u003e\n\u003cli\u003eLot-specific QC report + data sheet included with every kit\u003c\/li\u003e\n\u003cli\u003eAligned with \u003cstrong\u003eFDA DDI Guidance (2020)\u003c\/strong\u003e and \u003cstrong\u003eEMA DDI Guideline (2013\/2022)\u003c\/strong\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\n\u003ch3\u003eWhy Order via SeamlessBio?\u003c\/h3\u003e\n\u003ctable\u003e\n\u003ctr\u003e\n\u003cth\u003eAdvantage\u003c\/th\u003e\n\u003cth\u003eDescription\u003c\/th\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e✅ EU warehouse stock\u003c\/td\u003e\n\u003ctd\u003eFast cold-chain delivery across Germany, Austria, Switzerland and the EU\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e✅ Direct contact\u003c\/td\u003e\n\u003ctd\u003eSpeak to a scientist, not a call centre — in German or English\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e✅ Full documentation\u003c\/td\u003e\n\u003ctd\u003eData sheet, QC report and invoice with every shipment\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e✅ Batch reservation\u003c\/td\u003e\n\u003ctd\u003eReserve a specific lot for your entire project duration\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e✅ Complete portfolio\u003c\/td\u003e\n\u003ctd\u003eAll 11 Cell4Pharma kits from one source — BCRP, BSEP, MRP1–8, Pgp, Control\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/table\u003e\n\n\u003cp\u003eOrder or request pricing: \u003ca href=\"mailto:info@seamlessbio.de\"\u003einfo@seamlessbio.de\u003c\/a\u003e | +49 851 37932226\u003c\/p\u003e\n\n\u003ch3\u003eFrequently Asked Questions\u003c\/h3\u003e\n\u003ch4\u003eHow does MRP5 differ from MRP4 in substrate selectivity?\u003c\/h4\u003e\n\u003cp\u003eMRP4 and MRP5 share some substrates (cAMP, cGMP, PMEA) but differ in expression patterns and transport kinetics. MRP4 is more renal-dominant; MRP5 is ubiquitous with particularly notable CNS\/cardiac expression. Running both kits in parallel provides comprehensive nucleotide analogue profiling.\u003c\/p\u003e","brand":"Cell4Pharma","offers":[{"title":"100","offer_id":58031517925757,"sku":"C4PVK010","price":1450.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0916\/3338\/5853\/files\/MRP5-1-scaled.jpg?v=1776025628","url":"https:\/\/shop.seamlessbio.de\/en\/products\/mrp5-vesicle-kit","provider":"SeamlessBio","version":"1.0","type":"link"}