{"product_id":"human-bsep-vesicle-kit-hek293","title":"Human BSEP Vesicle Kit (HEK293-derived)","description":"\u003cdiv data-diff-type=\"normal\"\u003e\n\u003cmeta charset=\"utf-8\"\u003e\n\u003cdiv data-diff-type=\"normal\"\u003e\n\u003cdiv\u003eThe Human BSEP Vesicle Kit provides inside-out membrane vesicles\u003c\/div\u003e\n\u003c\/div\u003e\n\u003cdiv data-diff-type=\"normal\"\u003e\n\u003cdiv\u003eisolated from HEK293 cells transiently overexpressing the Bile Salt Export\u003c\/div\u003e\n\u003c\/div\u003e\n\u003cdiv data-diff-type=\"normal\"\u003e\n\u003cdiv\u003ePump (BSEP \/ ABCB11). BSEP is the primary hepatic efflux transporter for\u003c\/div\u003e\n\u003c\/div\u003e\n\u003cdiv data-diff-type=\"normal\"\u003e\n\u003cdiv\u003ebile salts and a critical target in drug-induced cholestasis (DILI) risk\u003c\/div\u003e\n\u003c\/div\u003e\n\u003cdiv data-diff-type=\"normal\"\u003e\n\u003cdiv\u003eassessment. The kit is compliant with FDA (2017) and EMA (2013) DDI guidance.\u003c\/div\u003e\n\u003c\/div\u003e\n\u003cdiv data-diff-type=\"normal\"\u003e\n\u003cdiv\u003e \u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003cdiv data-diff-type=\"normal\"\u003e\n\u003cdiv\u003eManufactured by Cell4Pharma.\u003c\/div\u003e\n\u003cdiv\u003eAvailable exclusively in the D-A-CH region via SeamlessBio.\u003c\/div\u003e\n\u003c\/div\u003e\n\u003cdiv data-diff-type=\"normal\"\u003e\n\u003cdiv\u003e\u003cbr\u003e\u003c\/div\u003e\n\u003cdiv\u003e\n\u003cmeta charset=\"utf-8\"\u003e\n\u003cdiv data-diff-type=\"normal\"\u003e\n\u003ch2\u003eTransporter Profile \u003c\/h2\u003e\n\u003c\/div\u003e\n\u003cdiv data-diff-type=\"normal\"\u003e\n\u003cdiv\u003e\n\u003cstrong\u003eName:\u003c\/strong\u003e BSEP, Bile Salt Export Pump, ABCB11, ATP-binding cassette sub-family B member 11\u003c\/div\u003e\n\u003c\/div\u003e\n\u003cdiv data-diff-type=\"normal\"\u003e\n\u003cdiv\u003e\n\u003cstrong\u003eGene: \u003c\/strong\u003e\u003cmeta charset=\"utf-8\"\u003eABCB11\u003c\/div\u003e\n\u003cdiv\u003e\n\u003cmeta charset=\"utf-8\"\u003e\n\u003cdiv data-diff-type=\"normal\"\u003e\n\u003cdiv\u003e\n\u003cstrong\u003eATP\/AMP ratio:\u003c\/strong\u003e \u0026gt;10 (guaranteed)\u003c\/div\u003e\n\u003c\/div\u003e\n\u003cdiv data-diff-type=\"normal\"\u003e\n\u003cdiv\u003e \u003c\/div\u003e\n\u003c\/div\u003e\n\u003cdiv data-diff-type=\"normal\"\u003e\n\u003cdiv\u003e\n\u003cstrong\u003eTissue expression: \u003c\/strong\u003e\u003cmeta charset=\"utf-8\"\u003eCanalicular plasma membrane of hepatocytes\u003c\/div\u003e\n\u003cdiv\u003e\n\u003cstrong\u003eDiseases:\u003c\/strong\u003e \u003cmeta charset=\"utf-8\"\u003eInherited and drug-induced cholestasis (DILI)\u003c\/div\u003e\n\u003c\/div\u003e\n\u003cdiv data-diff-type=\"normal\"\u003e\n\u003cdiv\u003e \u003c\/div\u003e\n\u003c\/div\u003e\n\u003cdiv data-diff-type=\"normal\"\u003e\n\u003cdiv\u003e\n\u003cstrong\u003eKnown substrates: \u003c\/strong\u003e \u003cmeta charset=\"utf-8\"\u003eTaurocholate, pravastatin, taurolitocholyl 3-sulfate, conjugated monovalent bile salts\u003c\/div\u003e\n\u003c\/div\u003e\n\u003cdiv data-diff-type=\"normal\"\u003e\n\u003cdiv\u003e\u003c\/div\u003e\n\u003cdiv\u003e\n\u003cstrong\u003eIn stock:\u003c\/strong\u003e \u003cmeta charset=\"utf-8\"\u003eHuman, cat, and dog BSEP\u003c\/div\u003e\n\u003cdiv\u003e\u003c\/div\u003e\n\u003cdiv\u003e\u003c\/div\u003e\n\u003ch2\u003e\n\u003cmeta charset=\"utf-8\"\u003e Kit Contents (100 Reactions)\u003c\/h2\u003e\n\u003cdiv\u003e\n\u003cdiv data-diff-type=\"normal\"\u003e\n\u003cul\u003e\n\u003cli\u003eVesicle vial (100 reactions), \u003cmeta charset=\"utf-8\"\u003eBSEP-overexpressing HEK293-derived\u003c\/li\u003e\n\u003cli\u003eAMP-ATP solution (100 mM), Cell4Pharma\u003c\/li\u003e\n\u003cli\u003eAssay buffer, Cell4Pharma\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/div\u003e\n\u003cdiv data-diff-type=\"normal\"\u003e\n\u003ch2\u003e\n\u003cmeta charset=\"utf-8\"\u003e Applications\u003c\/h2\u003e\n\u003cdiv\u003e\n\u003cmeta charset=\"utf-8\"\u003e\n\u003cdiv data-diff-type=\"normal\"\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cmeta charset=\"utf-8\"\u003eBile salt transport inhibition studies (cholestasis risk assessment)\u003c\/li\u003e\n\u003cli\u003eDrug-induced liver injury (DILI) screening\u003c\/li\u003e\n\u003cli\u003e\n\u003cmeta charset=\"utf-8\"\u003eDrug-drug interaction (DDI) studies per FDA\/EMA guidance\u003c\/li\u003e\n\u003cli\u003e\n\u003cmeta charset=\"utf-8\"\u003eSubstrate identification for hepatic efflux transporters\u003c\/li\u003e\n\u003cli\u003eHigh-throughput screening (radiolabel, fluorescent, LC-MS detection)\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch2\u003eRegulatory Compliance\u003c\/h2\u003e\n\u003cdiv data-diff-type=\"normal\"\u003e\n\u003cmeta charset=\"utf-8\"\u003e\n\u003cdiv data-diff-type=\"normal\"\u003e\n\u003cdiv\u003eBSEP inhibition is a well-established mechanism of drug-induced\u003c\/div\u003e\n\u003c\/div\u003e\n\u003cdiv data-diff-type=\"normal\"\u003e\n\u003cdiv\u003echolestatic liver injury. Assessment of BSEP inhibition is recommended in FDA (2017) and EMA (2013) DDI guidelines as part of the transporter characterization package for new molecular entities (NMEs) entering clinical development.\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003cdiv data-diff-type=\"normal\"\u003e\n\u003cdiv\u003e\u003cbr\u003e\u003c\/div\u003e\n\u003ch2\u003e\n\u003cmeta charset=\"utf-8\"\u003e Technical Specifications\u003c\/h2\u003e\n\u003cdiv data-diff-type=\"normal\"\u003e\n\u003cdiv\u003eHost cell: HEK293 (human embryonic kidney)\u003c\/div\u003e\n\u003c\/div\u003e\n\u003cdiv data-diff-type=\"normal\"\u003e\n\u003cdiv\u003eVesicle type: \u003cmeta charset=\"utf-8\"\u003eInside-out membrane vesicles\u003c\/div\u003e\n\u003c\/div\u003e\n\u003cdiv data-diff-type=\"normal\"\u003e\n\u003cdiv\u003eFormat: 100 reactions per kit\u003c\/div\u003e\n\u003c\/div\u003e\n\u003cdiv data-diff-type=\"normal\"\u003e\n\u003cdiv\u003eDetection: \u003cmeta charset=\"utf-8\"\u003eRadiolabel \/ fluorescent \/ LC-MS compatible\u003c\/div\u003e\n\u003c\/div\u003e\n\u003cdiv data-diff-type=\"normal\"\u003e\n\u003cdiv\u003eStorage: –80 °C\u003c\/div\u003e\n\u003cdiv\u003e\u003cbr\u003e\u003c\/div\u003e\n\u003ch2\u003e\n\u003cmeta charset=\"utf-8\"\u003eCross-References \u0026amp; Related Products\u003c\/h2\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003cdiv data-diff-type=\"normal\"\u003e\n\u003cmeta charset=\"utf-8\"\u003e\n\u003cdiv data-diff-type=\"normal\"\u003e\n\u003cul\u003e\n\u003cli\u003eHuman Control Vesicle Kit (C4PVK009) – recommended as negative control\u003c\/li\u003e\n\u003cli\u003eHuman MRP2 Vesicle Kit (C4PVK002) – for parallel hepatic efflux assessment\u003c\/li\u003e\n\u003cli\u003eHuman BCRP Vesicle Kit (C4PVK006) – for complete efflux transporter panel\u003c\/li\u003e\n\u003cli\u003eciPTEC-OAT1 Assay-Ready Cells – for cell-based nephrotoxicity studies\u003c\/li\u003e\n\u003cli\u003eHuman Serum AB Male OTC (SeamlessBio) – for ciPTEC culture medium supplementation\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003cdiv data-diff-type=\"normal\"\u003e\n\u003cdiv\u003e\n\u003cdiv data-diff-type=\"normal\"\u003e\n\u003cdiv\u003eAll products available on request.\u003c\/div\u003e\n\u003cdiv\u003eContact: info@seamlessbio.de | Phone: +49 851 37932226\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003cdiv\u003e\u003cbr\u003e\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e","brand":"SeamlessBio","offers":[{"title":"100","offer_id":57983601443197,"sku":"C4PVK007","price":1450.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0916\/3338\/5853\/files\/Human_BSEP_Vesicle_Kit.png?v=1776025807","url":"https:\/\/shop.seamlessbio.de\/en\/products\/human-bsep-vesicle-kit-hek293","provider":"SeamlessBio","version":"1.0","type":"link"}