{"product_id":"human-bcrp-vesicle-kit-hek293","title":"Human BCRP Vesicle Kit (HEK293-derived)","description":"\u003cdiv data-diff-type=\"normal\"\u003e\n\u003cdiv\u003eThe Human BCRP Vesicle Kit provides inside-out membrane vesicles\u003c\/div\u003e\n\u003c\/div\u003e\n\u003cdiv data-diff-type=\"normal\"\u003e\n\u003cdiv\u003eisolated from HEK293 cells transiently overexpressing the Breast Cancer\u003c\/div\u003e\n\u003c\/div\u003e\n\u003cdiv data-diff-type=\"normal\"\u003e\n\u003cdiv\u003eResistance Protein (BCRP \/ ABCG2). The kit enables ATP-dependent substrate\u003c\/div\u003e\n\u003c\/div\u003e\n\u003cdiv data-diff-type=\"normal\"\u003e\n\u003cdiv\u003etransport studies in a high-throughput format and is compliant with FDA (2017)\u003c\/div\u003e\n\u003c\/div\u003e\n\u003cdiv data-diff-type=\"normal\"\u003e\n\u003cdiv\u003eand EMA (2013) guidance for drug-drug interaction (DDI) characterization.\u003c\/div\u003e\n\u003c\/div\u003e\n\u003cdiv data-diff-type=\"normal\"\u003e\n\u003cdiv\u003e \u003c\/div\u003e\n\u003c\/div\u003e\n\u003cdiv data-diff-type=\"normal\"\u003e\n\u003cdiv\u003eManufactured by Cell4Pharma.\u003c\/div\u003e\n\u003cdiv\u003eAvailable exclusively in the DACH region via SeamlessBio.\u003c\/div\u003e\n\u003c\/div\u003e\n\u003cdiv data-diff-type=\"normal\"\u003e\n\u003cdiv\u003e\u003c\/div\u003e\n\u003cdiv\u003e\n\u003cmeta charset=\"utf-8\"\u003e\n\u003cdiv data-diff-type=\"normal\"\u003e\n\u003ch2\u003eTransporter Profile \u003c\/h2\u003e\n\u003c\/div\u003e\n\u003cdiv data-diff-type=\"normal\"\u003e\n\u003cdiv\u003e\n\u003cstrong\u003eName: \u003c\/strong\u003eBCRP, Breast Cancer Resistance Protein, ABCG2,\u003c\/div\u003e\n\u003c\/div\u003e\n\u003cdiv data-diff-type=\"normal\"\u003e\n\u003cdiv\u003eATP-binding cassette sub-family G member 2\u003c\/div\u003e\n\u003c\/div\u003e\n\u003cdiv data-diff-type=\"normal\"\u003e\n\u003cdiv\u003e\n\u003cstrong\u003eGene:\u003c\/strong\u003e ABCG2\u003c\/div\u003e\n\u003cdiv\u003e\n\u003cmeta charset=\"utf-8\"\u003e\n\u003cdiv data-diff-type=\"normal\"\u003e\n\u003cdiv\u003e\n\u003cstrong\u003eATP\/AMP ratio:\u003c\/strong\u003e \u0026gt;10 (guaranteed)\u003c\/div\u003e\n\u003c\/div\u003e\n\u003cdiv data-diff-type=\"normal\"\u003e\n\u003cdiv\u003e \u003c\/div\u003e\n\u003c\/div\u003e\n\u003cdiv data-diff-type=\"normal\"\u003e\n\u003cdiv\u003e\n\u003cstrong\u003eTissue expression:\u003c\/strong\u003e Placenta, stem cells, prostate, small intestine, brain,\u003c\/div\u003e\n\u003c\/div\u003e\n\u003cdiv data-diff-type=\"normal\"\u003e\n\u003cdiv\u003ecolon, liver, mammary gland, kidney\u003c\/div\u003e\n\u003c\/div\u003e\n\u003cdiv data-diff-type=\"normal\"\u003e\n\u003cdiv\u003e \u003c\/div\u003e\n\u003c\/div\u003e\n\u003cdiv data-diff-type=\"normal\"\u003e\n\u003cdiv\u003e\n\u003cstrong\u003eKnown substrates:\u003c\/strong\u003e Estrone-3-sulfate (E1S), methotrexate, irinotecan,\u003c\/div\u003e\n\u003c\/div\u003e\n\u003cdiv data-diff-type=\"normal\"\u003e\n\u003cdiv\u003epantoprazole, rosuvastatin, topotecan, chlorothiazide, mitoxantrone, SN-38, glyburide\u003c\/div\u003e\n\u003c\/div\u003e\n\u003cdiv data-diff-type=\"normal\"\u003e\n\u003cdiv\u003e\u003cbr\u003e\u003c\/div\u003e\n\u003ch2\u003e\n\u003cmeta charset=\"utf-8\"\u003e Kit Contents (100 Reactions)\u003c\/h2\u003e\n\u003cdiv\u003e\n\u003cdiv data-diff-type=\"normal\"\u003e\n\u003cdiv\u003eVesicle vial (100 reactions), BCRP-overexpressing HEK293-derived\u003c\/div\u003e\n\u003c\/div\u003e\n\u003cdiv data-diff-type=\"normal\"\u003e\n\u003cdiv\u003eAMP-ATP solution (100 mM), Cell4Pharma\u003c\/div\u003e\n\u003c\/div\u003e\n\u003cdiv data-diff-type=\"normal\"\u003e\n\u003cdiv\u003eAssay buffer, Cell4Pharma\u003c\/div\u003e\n\u003cdiv\u003e\u003cbr\u003e\u003c\/div\u003e\n\u003ch2\u003e\n\u003cmeta charset=\"utf-8\"\u003e Applications\u003c\/h2\u003e\n\u003cdiv\u003e\n\u003cmeta charset=\"utf-8\"\u003e\n\u003cdiv data-diff-type=\"normal\"\u003e\n\u003cul\u003e\n\u003cli\u003eDrug-drug interaction (DDI) studies per FDA\/EMA guidance\u003c\/li\u003e\n\u003cli\u003eInhibition studies (IC50 determination)\u003c\/li\u003e\n\u003cli\u003eHigh-throughput screening (radiolabel, fluorescent, LC-MS detection)\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch2\u003e\n\u003cmeta charset=\"utf-8\"\u003e Regulatory Compliance\u003c\/h2\u003e\n\u003cdiv data-diff-type=\"normal\"\u003e\n\u003cdiv\u003eThe vesicular transport assay using BCRP vesicles is recommended by\u003c\/div\u003e\n\u003c\/div\u003e\n\u003cdiv data-diff-type=\"normal\"\u003e\n\u003cdiv\u003ethe FDA Drug Interaction Guidance (2017) and EMA Guideline on the\u003c\/div\u003e\n\u003c\/div\u003e\n\u003cdiv data-diff-type=\"normal\"\u003e\n\u003cdiv\u003eInvestigation of Drug Interactions (2013) for the characterization of transporter-mediated DDI during drug development.\u003c\/div\u003e\n\u003cdiv\u003e\u003cbr\u003e\u003c\/div\u003e\n\u003ch2\u003e\n\u003cmeta charset=\"utf-8\"\u003e Technical Specifications\u003c\/h2\u003e\n\u003cdiv data-diff-type=\"normal\"\u003e\n\u003cdiv\u003eHost cell: HEK293 (human embryonic kidney)\u003c\/div\u003e\n\u003c\/div\u003e\n\u003cdiv data-diff-type=\"normal\"\u003e\n\u003cdiv\u003eVesicle type: Inside-out membrane vesicles\u003c\/div\u003e\n\u003c\/div\u003e\n\u003cdiv data-diff-type=\"normal\"\u003e\n\u003cdiv\u003eFormat: 100 reactions per kit\u003c\/div\u003e\n\u003c\/div\u003e\n\u003cdiv data-diff-type=\"normal\"\u003e\n\u003cdiv\u003eDetection: Radiolabel \/ fluorescent \/ LC-MS compatible\u003c\/div\u003e\n\u003c\/div\u003e\n\u003cdiv data-diff-type=\"normal\"\u003e\n\u003cdiv\u003eStorage: –80 °C\u003c\/div\u003e\n\u003cdiv\u003e\u003c\/div\u003e\n\u003ch2\u003e\n\u003cmeta charset=\"utf-8\"\u003eCross-References \u0026amp; Related Products\u003c\/h2\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003cdiv data-diff-type=\"normal\"\u003e\n\u003cdiv\u003eHuman Control Vesicle Kit (C4PVK009) – recommended as negative\u003c\/div\u003e\n\u003c\/div\u003e\n\u003cdiv data-diff-type=\"normal\"\u003e\n\u003cdiv\u003econtrol in BCRP transport assays\u003c\/div\u003e\n\u003cdiv\u003eHuman Pgp Vesicle Kit (C4PVK010) – for parallel P-gp efflux assessment\u003c\/div\u003e\n\u003cdiv\u003eciPTEC-OAT1 Assay-Ready Cells – for cell-based nephrotoxicity and\u003c\/div\u003e\n\u003c\/div\u003e\n\u003cdiv data-diff-type=\"normal\"\u003e\n\u003cdiv\u003etransporter studies\u003c\/div\u003e\n\u003cdiv\u003eHuman Serum AB Male OTC (SeamlessBio) – for ciPTEC culture medium supplementation\u003c\/div\u003e\n\u003cdiv\u003e\u003cbr\u003e\u003c\/div\u003e\n\u003cdiv\u003e\n\u003cdiv data-diff-type=\"normal\"\u003e\n\u003cdiv\u003eAll products available on request.\u003c\/div\u003e\n\u003cdiv\u003eContact: info@seamlessbio.de | Phone: +49 851 37932226\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003cdiv\u003e\u003cbr\u003e\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e","brand":"SeamlessBio","offers":[{"title":"100","offer_id":57980317499773,"sku":"C4PVK006","price":1450.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0916\/3338\/5853\/files\/Human_BCRP_vesicle_kit.png?v=1776025806","url":"https:\/\/shop.seamlessbio.de\/en\/products\/human-bcrp-vesicle-kit-hek293","provider":"SeamlessBio","version":"1.0","type":"link"}